General Cell Lines and Cell Cultures
Biolegend TotalSeqTM-B0909 anti-mouse CD
TotalSeq™-B0909 anti-mouse CD182 (CXCR2) [SA044G4]; Isotype: Rat IgG2a, κ; Reactivity: Mouse; Apps: PG; Size: 10 μg
ABclonal Technology MC5 Receptor Rabbit mAb
This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation.
Amsbio LLC MDA5/NF-kB Leeporter™ Luciferase Reporter-HEK293T Cell Line
MDA5/NF-kB Leeporter™ Luciferase Reporter-HEK293T Cell Line
ATCC HCM-CSHL-0062-C18; Primary Adenocarcinoma Rectosigmoid junction; Human (Homo sapiens)
A patient-derived next-generation cancer model generated by the Human Cancer Models Initiative (HCMI). HCM-CSHL-0062-C18 (ATCC No. PDM-6) was isolated from primary adenocarcinoma of large intestine tissue. This tumor-derived model can be used in basic research and pharmacological screening applications. Data for the parental tumor and the tumor-derived organoid models are available at the GDC. Additional molecular characterizations may be available at the GDC. Additional controlled data may be available via dbGaP.
ATCC Neisseria gonorrhoeae; genomic DNA
Genomic DNA isolated from Neisseria gonorrhoeae strain [ATCC 31426]. This bacterial strain is also available as ATCC Catalog No.: 53422™.
Eurofins Discoverx PathHunter CHRM1 Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0655C3)
The PathHunter CHRM1 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of CHRM1 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged CHRM1. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting CHRM1-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx ChemiScreen V2 Vasopressin Receptor Stable Cell Line, 2 vials. (HTS060C)
The ChemiScreen V2 Vasopressin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. vasopressin) based activation of AVPR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses AVPR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of AVPR2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen PRP/GPR10 Prolactin-Releasing Peptide Receptor Membrane Preparation, 1 vial. (HTS057M)
The ChemiScreen PRP/GPR10 Prolactin-Releasing Peptide Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of PRLHR surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach or to screen for GPCR activity using GTPγS assays. Increased binding affinities or GPCR activation levels will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx ChemiScreen κ Opioid Receptor Membrane Preparation, 1 vial. (HTS095M)
The ChemiScreen κ Opioid Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of OPRK1 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx KILR HT-1080 Cell Pool, 2 vials. (97-1031P043)
The KILR HT-1080 cell pool is a stable, engineered target cell pool, which closely reflects the heterogeneous native protein expression of tumor environments, used to measure direct cell death mediated by immunooncology treatments (e.g. checkpoint modulators, bispecifics, CAR-T, etc.) via Antibody Dependent Cell-mediated Cytotoxicity (ADCC), Complement Dependent Cytotoxicity (CDC), and Antibody Dependent Cell Phagocytosis (ADCP). This product uses EFC technology. The cell pool is a heterogeneous population of HT-1080 cells that overexpress a ProLabel-tagged housekeeping gene. Upon effector cells-mediated cell lysis, ProLabel is released to the media, where EA in the detection kit produces an EFC signal proportional to the level of ProLabel released. This allows for calculation of percent lysis of the KILR cell pool. This stable cell pool is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kilr.
ATCC Vibrio parahaemolyticus; Strain EB 101; genomic DNA
Genomic DNA isolated from Vibrio parahaemolyticus strain EB 101 (ATCC 17802). This whole-genome sequenced product can be used in PCR and other molecular biology applications.
STEMCELL Technologies Human Whole Peripheral Blood Collected with ACDA, Fresh, Size: 150 mL
Normal whole peripheral blood (PB) is obtained from healthy donors using Institutional Review Board (IRB)-approved consent forms and protocols. Acid citrate dextrose, solution A (ACDA), Sodium Heparin (Na-Hep), Ethylenediaminetetraacetic acid (EDTA), or Citrate-phosphate-double-dextrose (CP2D) is the anticoagulant.Certain products are only available in select territories. Please contact your local Sales representative or Product & Scientific Support at techsupport@stemcell.com for further information and to inquire about donor selection or information including BMI category, smoking status, ethnicity, etc.Browse our Frequently Asked Questions (FAQs) (https://www.stemcell.com/primary-cells-faq) on Primary Cells.
Biolegend Ultra-LEAFTM Purified anti-hum
Ultra-LEAF™ Purified anti-human CD282 (TLR2) [TL2.1]; Isotype: Mouse IgG2a, κ; Reactivity: Human; Apps: FC, Block, IHC-P, IHC-F, IP, WB; Size: 1 mg
ATCC Epicoccum nigrum
An ampoule containing viable cells (may include spores and mycelia) suspended in cryoprotectant.